Guard B C, Wiltshire S J
Department of Anaesthesia, Ipswich Hospital, Suffolk.
Anaesthesia. 1996 Dec;51(12):1173-5. doi: 10.1111/j.1365-2044.1996.tb15064.x.
In order to evaluate the contribution of tubal spasm to pelvic pain following laparoscopic sterilisation, we have studied the effect of glycopyrrolate, an anticholinergic agent with antispasmodic properties, on 60 ASA 1 and 2 patients presenting as day-cases for laparoscopic sterilisation using Filshie clips. In a randomised, double-blind, controlled trial, patients received either glycopyrrolate 0.3 mg or saline intravenously prior to induction of anaesthesia. Compared with the control group, patients receiving glycopyrrolate had significantly reduced immediate postoperative pain scores (p < 0.02) and required significantly less postoperative morphine (p < 0.01). Nausea, vomiting and anti-emetic requirements were also reduced though not significantly. We conclude that glycopyrrolate 0.3 mg at induction of anaesthesia is an effective method of improving the quality of recovery after day-case laparoscopic sterilisation using clips.
为了评估输卵管痉挛对腹腔镜绝育术后盆腔疼痛的影响，我们研究了格隆溴铵（一种具有解痉特性的抗胆碱能药物）对60例ASA 1级和2级患者的作用，这些患者作为日间手术接受使用Filshie夹的腹腔镜绝育术。在一项随机、双盲、对照试验中，患者在麻醉诱导前静脉注射0.3 mg格隆溴铵或生理盐水。与对照组相比，接受格隆溴铵的患者术后即刻疼痛评分显著降低（p < 0.02），术后所需吗啡量显著减少（p < 0.01）。恶心、呕吐及止吐药物的使用需求也有所减少，尽管差异不显著。我们得出结论，麻醉诱导时使用0.3 mg格隆溴铵是提高日间腹腔镜夹闭绝育术后恢复质量的有效方法。
