Zieren H U, Jacobi C A, Zieren J, Müller J M
Department of Surgery, Charité, Humoldt University of Berlin, Germany.
Br J Surg. 1996 Dec;83(12):1772-5. doi: 10.1002/bjs.1800831235.
Quality of life following resection of oesophageal carcinoma was assessed by patients using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and by a psychologist using the Spitzer Index. Quality of life was evaluated in 119 patients on one occasion 12 months after operation and in 30 patients regularly, starting with a preoperative assessment. Self and external evaluation showed a significant correlation (r = 0.61), but quality of life was assessed as being higher by the external observer. Limited physical performance status and somatic complaints were the most important postoperative dysfunctions, whereas emotional, social and economic disorders were found to be less frequent and less severe. Of several factors analysed only tumour recurrence (P < 0.01) and anastomotic stricture (P < 0.05) lowered quality of life significantly. Compared with the preoperative assessment, quality of life had decreased on discharge from hospital but was restored within 6 months of operation in disease-free patients. Further studies are required to determine the impact of adjuvant therapy for quality of life in patients undergoing surgery for oesophageal cancer.
患者使用欧洲癌症研究与治疗组织生活质量问卷，心理学家使用斯皮策指数对食管癌切除术后的生活质量进行评估。对119例患者在术后12个月进行了一次生活质量评估，对30例患者从术前评估开始进行定期评估。自我评估和外部评估显示出显著相关性（r = 0.61），但外部观察者评估的生活质量更高。身体活动能力受限和躯体不适是最重要的术后功能障碍，而情感、社会和经济障碍的发生频率较低且严重程度较轻。在分析的几个因素中，只有肿瘤复发（P < 0.01）和吻合口狭窄（P < 0.05）显著降低了生活质量。与术前评估相比，出院时生活质量有所下降，但无疾病患者在术后6个月内恢复。需要进一步研究以确定辅助治疗对接受食管癌手术患者生活质量的影响。
