Zieren H U, Jacobi C A, Zieren J, Müller J M
Klinik und Poliklinik für Chirurgie der Charité, Humboldt-Universität zu Berlin.
Chirurg. 1996 Jul;67(7):703-8; discussion 709.
Quality of life (QL) following resection of carcinoma of the colon (n = 68) and rectum (n = 58) was studied in 126 patients 12 months postoperatively and in 34 patients at regularly intervals, starting with a preoperative assessment. QL was assessed by the patients themselves using the EORTC QL questionnaire (QLQ-30) and by a psychologist using the Spitzer index. Between self-assessment and evaluation by the independent observer, a significant but not very strong correlation (r = 0.48) was determined and QL was evaluated as being better by the observer. Although somatic and emotional problems were significantly more common in patients with rectal cancer following abdominoperineal resection and the Spitzer index was significantly lower in these patients, the subjectively perceived global QL did not differ from that after sphincter-preserving resection. Of several factors analysed, tumour recurrence was the decisive factor determining postoperative QL. In disease-free patients QL had deteriorated on discharge from hospital but was restored within 3-6 months postoperatively.
对126例结肠癌（n = 68）和直肠癌（n = 58）患者在术后12个月进行了生活质量（QL）研究，并对34例患者从术前评估开始定期进行研究。患者自身使用欧洲癌症研究与治疗组织生活质量问卷（QLQ - 30）评估生活质量，心理学家使用斯皮策指数进行评估。在自我评估和独立观察者评估之间，确定了显著但不太强的相关性（r = 0.48），观察者评估的生活质量更好。尽管腹会阴切除术后直肠癌患者的躯体和情感问题明显更常见，且这些患者的斯皮策指数明显更低，但主观感知的总体生活质量与保留括约肌切除术后并无差异。在分析的几个因素中，肿瘤复发是决定术后生活质量的决定性因素。无疾病患者出院时生活质量恶化，但术后3 - 6个月内恢复。
