Ueta E, Miki T, Osaki T, Iwata J, Sonobe H
Department of Oral Surgery, Kochi Medical School, Japan.
Eur J Cancer B Oral Oncol. 1996 Nov;32B(6):423-7. doi: 10.1016/s0964-1955(96)00036-x.
A rare case of desmoplastic melanoma arising from the maxillary gingiva of a 66-year-old woman is reported. This tumour metastasised to the submandibular lymph node 5 years after extirpation, and local recurrence was observed 2 years later. The gingival tumour showed the histopathological characteristics of desmoplastic melanoma and the metastasised tumour cells were immunohistochemically positive for S-100 protein, neuron specific enolase, HMB-45 highly specific for conventional melanoma, and Fontana-Masson staining. The gingival tumour, originally regarded as benign clinically, was actually a desmoplastic melanoma.
报告了一例罕见的发生于一名66岁女性上颌牙龈的促纤维增生性黑色素瘤。该肿瘤在切除后5年转移至下颌下淋巴结，并于2年后出现局部复发。牙龈肿瘤显示出促纤维增生性黑色素瘤的组织病理学特征，转移的肿瘤细胞免疫组化显示S-100蛋白、神经元特异性烯醇化酶、对传统黑色素瘤高度特异的HMB-45以及Fontana-Masson染色均呈阳性。该牙龈肿瘤最初在临床上被认为是良性的，实际上却是促纤维增生性黑色素瘤。
