Medzhitov R, Janeway C A
Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, PO Box 208011, New Haven, CT 06520-8011, USA.
Curr Opin Immunol. 1997 Feb;9(1):4-9. doi: 10.1016/s0952-7915(97)80152-5.
For many years, innate immunity has been considered as a separate entity from the adaptive immune response and has been regarded to be of secondary importance in the hierarchy of immune functions. For the past few years, however, interest in innate immunity has grown enormously, so that now it is studied intensively in many laboratories that seek to integrate these two distinct types of immune function. Our intent in this review is to point out the similarities and differences in these two types of host response to infection, and to indicate our present level of understanding of how these can be integrated into a more complete description of the immune response.
多年来，固有免疫一直被视为与适应性免疫应答相互独立的实体，并且在免疫功能层级中被认为是次要的。然而，在过去几年里，对固有免疫的关注大幅增加，以至于现在许多实验室都在深入研究它，试图将这两种不同类型的免疫功能整合起来。我们撰写这篇综述的目的是指出这两种宿主对感染的应答类型的异同，并说明我们目前对于如何将它们整合为对免疫应答更完整描述的理解水平。
