Boismenu R, Havran W L
Department of Immunology, The Scripps Research Institute, IMM-8, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Curr Opin Immunol. 1997 Feb;9(1):57-63. doi: 10.1016/s0952-7915(97)80159-8.
Findings made during the past few years demonstrate that gamma delta T cells apparently share with macrophages a propensity to recognize nonpeptidic molecules of the kind most commonly associated with microorganisms and stressed cells. In general, recognition of these antigens by gamma delta T cells involves the antigen receptor but does not require antigen presenting cells to express MHC gene products or to have a functional antigen processing machinery. Other recent advances continue to support the notion that gamma delta T cells can perform specialized functions related to the repair of tissue damage.
过去几年的研究结果表明，γδ T细胞显然与巨噬细胞一样，倾向于识别那些最常与微生物和应激细胞相关的非肽类分子。一般来说，γδ T细胞对这些抗原的识别涉及抗原受体，但不需要抗原呈递细胞表达MHC基因产物或具备功能性的抗原加工机制。最近的其他进展继续支持γδ T细胞能够执行与组织损伤修复相关的特殊功能这一观点。
