Sartorius O W, Smith H S, Morris P, Benedict D, Friesen L
J Natl Cancer Inst. 1977 Oct;59(4):1073-80. doi: 10.1093/jnci/59.4.1073.
The availability and cell content of aspirated breast fluid from 1,706 women were evaluated to determine the usefulness of breast fluid cytology as an indicator of breast disease. A newly developed aspirator was used to obtain cells adequate for diagnosis from approximately 50% of the women tested. Fluids were most readily available from women between the ages of 30 and 50 years. Although abnormal cytologies were observed in all age groups, the relative proportion of abnormal specimens as well as the degree of abnormality increased as a function of age. More women over 40 years of age with a high risk of breast cancer had cells classified in the more abnormal categories than did women in the normal risk group. To localize otherwise occult lesions, contrast ductography was performed on all women with very abnormal ductal cells. Women with atypical hyperplastic cytologies most commonly had benign and premalignant breast disease at subsequent biopsy. Of 27 women with fluids classified as suspected carcinomas 18 (66%) had small carcinomas. These observations strongly suggested that the presence of atypical cells in aspirated breast fluids has important clinical application for early detection of breast cancer. One limitation of cytology was that the technique rarely detected carcinomas greater than 1 cm.
对1706名女性的吸出乳腺液的可获取性和细胞含量进行了评估，以确定乳腺液细胞学作为乳腺疾病指标的有用性。一种新开发的抽吸器被用于从大约50%接受检测的女性中获取足以用于诊断的细胞。年龄在30至50岁之间的女性最容易获取到液体。虽然在所有年龄组中都观察到了异常细胞学情况，但异常标本的相对比例以及异常程度随年龄增长而增加。与正常风险组的女性相比，40岁以上患乳腺癌风险高的女性中，细胞被分类为更异常类别的更多。为了定位其他隐匿性病变，对所有导管细胞非常异常的女性进行了对比导管造影。非典型增生细胞学的女性在随后的活检中最常见的是良性和癌前乳腺疾病。在27名液体被分类为疑似癌的女性中，18名（66%）患有小癌。这些观察结果强烈表明，吸出乳腺液中存在非典型细胞对乳腺癌的早期检测具有重要的临床应用价值。细胞学的一个局限性是该技术很少能检测到大于1厘米的癌。
