Luton D, Sibony O, Oury J F, Blot P, Dieterlen-Lièvre F, Pardanaud L
Maternity unit, Robert Debre Hospital, Paris, France.
Early Hum Dev. 1997 Jan 20;47(2):147-56. doi: 10.1016/s0378-3782(96)01775-6.
Expression of the c-Ets1 protooncogene which codes for a transcription factor is associated with neovascularization and invasive processes. In order to determine c-Ets1 expression at the mRNA level, during the process of implantation during the first trimester of human pregnancy, samples of trophoblast were retrieved at the time of legal abortion and processed for in situ hybridization. We found that c-Ets1 mRNAs are transcribed in the endothelial cells of villous trophoblast and in the extravillous trophoblastic cells invading the uterine vessels. However, no transcript was found in maternal endothelial cells. We conclude that c-Ets1 plays a role in angiogenesis occurring in the development of the villous tree and is involved during the invasive process of the endometrium and maternal vessels by trophoblastic cells; this latter physiological event is crucial for a normal development of the fetus, its failure leading to pathological cases. We suggest that the role of the c-Ets1 protooncogene is related to the regulation of metalloproteinase genes transcription, a gene family which is known to be a target for Ets protein.
编码一种转录因子的原癌基因c-Ets1的表达与新血管形成和侵袭过程相关。为了确定在人类妊娠头三个月着床过程中c-Ets1在mRNA水平的表达情况，在合法堕胎时获取滋养层样本，并进行原位杂交处理。我们发现，c-Ets1 mRNA在绒毛滋养层的内皮细胞以及侵入子宫血管的绒毛外滋养层细胞中被转录。然而，在母体内皮细胞中未发现转录本。我们得出结论，c-Ets1在绒毛树发育过程中发生的血管生成中起作用，并在滋养层细胞对子宫内膜和母体血管的侵袭过程中发挥作用；后一生理事件对胎儿的正常发育至关重要，其失败会导致病理情况。我们认为，原癌基因c-Ets1的作用与金属蛋白酶基因转录的调控有关，金属蛋白酶基因家族是已知的Ets蛋白靶点。
