Kostner K M, Jansen M, Maurer G, Derfler K
Department of Cardiology, University Hospital of Vienna, Waehringerguertel.
Eur J Clin Invest. 1997 Jan;27(1):93-5. doi: 10.1046/j.1365-2362.1997.00108.x.
Increased plasma Lp(a) is an established risk factor for atherosclerosis. We recently described the presence of apo(a) fragments in urine and the significant correlation between urinary apo(a) concentrations and plasma Lp(a). Here we investigated urinary apo(a) in patients suffering from familial hypercholesterolaemia (FH), treated with LDL apheresis. Before treatment, plasma Lp(a) levels and urinary apo(a) normalized to creatinine were > 2-fold increased in FH patients (P < 0.0001) as compared to controls. LDL-apheresis led to a reduction of plasma Lp(a) by 75% and a concomitant immediate reduction of urinary apo(a) by 45%. We conclude that a steady state condition for urinary apo(a) is rapidly achieved via LDL-apheresis.
血浆Lp(a)升高是动脉粥样硬化的既定危险因素。我们最近描述了尿液中载脂蛋白(a)片段的存在以及尿载脂蛋白(a)浓度与血浆Lp(a)之间的显著相关性。在此，我们研究了接受低密度脂蛋白单采治疗的家族性高胆固醇血症（FH）患者的尿载脂蛋白(a)情况。治疗前，与对照组相比，FH患者的血浆Lp(a)水平和以肌酐标准化的尿载脂蛋白(a)升高了2倍以上（P<0.0001）。低密度脂蛋白单采使血浆Lp(a)降低了75%，同时尿载脂蛋白(a)立即降低了45%。我们得出结论，通过低密度脂蛋白单采可迅速实现尿载脂蛋白(a)的稳态。
