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[化脓性链球菌在摩洛哥咽喉感染中的地位及其对抗生素敏感性概述]

[Place of Streptococcus pyogenes in the throat infection in Morocco and overview of its susceptibility to antibiotics].

作者信息

Benouda A, Sibile S, Ziane Y, Elouennass M, Dahani K, Hassani A

机构信息

Laboratoire de microbiologie-virologie, hôpital universitaire Cheick-Zaid, avenue Allal El Fassi, Madinat Al Irfane Hay Riyad, 1100 Rabat, Maroc.

出版信息

Pathol Biol (Paris). 2009 Feb;57(1):76-80. doi: 10.1016/j.patbio.2008.08.003. Epub 2008 Dec 17.

Abstract

OBJECTIVE

In this study we report the prevalence of the throat infections to Streptococcus pyogenes in child and adult in Morocco, and the current antimicrobial susceptibility of the aminopenicillins and erythromycin.

PATIENTS AND METHODS

A prospective surveillance study was made from March 2006 to February 2007 in four primary health care in Rabat and Sale cities. Six hundred and ninety-seven patients (494 children and 203 adults) were the object of samplings by throat cotton swab probe, for researching the group A Streptococcus (GAS). The patients were those proposed by their doctors for the treatment of throat infections. The antimicrobial susceptibility was realized by two methods: the disc-diffusion method on Mueller-Hinton agar plates and MICs were determined by E-test. The antibiotics tested were the penicillin G, the amoxicillin and the erythromycin.

RESULTS

S. pyogenes was identified in 65 cases (9.3%): 45 strains in children (9.1%) and 20 strains in adults (9.9%). Two peaks of throat infections to S. pyogenes were recorded in children aged 12 to 15 years and in adults between 36 and 39 years old. All strains were susceptible to penicillin G and amoxicillin. One strain was resistant to erythromycin with a MIC greater than 256 microg/mL.

摘要

目的

在本研究中,我们报告了摩洛哥儿童和成人中化脓性链球菌引起的咽喉感染的患病率,以及氨基青霉素和红霉素目前的抗菌药敏情况。

患者与方法

2006年3月至2007年2月在拉巴特和萨勒市的四家初级卫生保健机构进行了一项前瞻性监测研究。697名患者(494名儿童和203名成人)接受了咽喉棉拭子采样,以检测A组链球菌(GAS)。这些患者是由他们的医生推荐来治疗咽喉感染的。抗菌药敏试验通过两种方法进行:在Mueller-Hinton琼脂平板上采用纸片扩散法,并用E-test法测定最低抑菌浓度(MIC)。检测的抗生素为青霉素G、阿莫西林和红霉素。

结果

共鉴定出65例化脓性链球菌感染(9.3%):儿童45株(9.1%),成人20株(9.9%)。12至15岁儿童和36至39岁成人中出现了两个化脓性链球菌咽喉感染高峰。所有菌株对青霉素G和阿莫西林敏感。有1株对红霉素耐药,其MIC大于256μg/mL。

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