Gaykema R P, Zaborszky L
Center for Molecular and Behavioral Neuroscience, Ratgers University, Newark, NJ 07102, USA.
Brain Res. 1997 Jan 30;747(1):173-9. doi: 10.1016/s0006-8993(96)01309-1.
By means of anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) it was determined if parvalbumin-immunoreactive neurons in the basal forebrain receive a direct synaptic input from the A9-A10 dopaminergic nuclei of the substantia nigra and ventral tegmental area. Forebrain sections were processed for immunocytochemical detection of PHA-L and parvalbumin (PV) at light and electron microscopic levels. At the ultrastructural level, PHA-L-labeled terminals were found to establish synaptic contacts with PV-immunoreactive neuronal somata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substantia innominata. PV-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably A9-A10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity.
通过菜豆白细胞凝集素（PHA-L）顺行示踪法，确定基底前脑中小清蛋白免疫反应性神经元是否接受来自黑质A9-A10多巴胺能核团和腹侧被盖区的直接突触输入。对前脑切片进行处理，以便在光学和电子显微镜水平上对PHA-L和小清蛋白（PV）进行免疫细胞化学检测。在超微结构水平上，发现PHA-L标记的终末与腹内侧苍白球、腹侧苍白球、内囊和无名质中的PV免疫反应性神经元胞体建立突触联系。因此，苍白球及相邻基底前脑区域中含PV的神经元是假定的A9-A10多巴胺能神经元的直接靶点，这代表了中脑多巴胺能对基底前脑神经元活动控制的一个新方面。
