Okamoto E, Haruma K, Hata J, Tani H, Sumii K, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Aliment Pharmacol Ther. 1997 Feb;11(1):177-84. doi: 10.1046/j.1365-2036.1997.128298000.x.
Somatostatin exerts inhibitory effects on physiological functions in the gastrointestinal tract. The actions differ, however, depending on the test meal, dose, and other factors.
To determine by use of ultrasonography and scintigraphy the effect of a somatostatin analog, octreotide, on gastric emptying and antral contraction.
Twenty healthy men; mean age 23.9 years
Subjects were studied for 7 days, once after subcutaneous injection of octreotide, 50 microg, 5 min before the ingestion of a test meal and once after subcutaneous injection of placebo. Ten subjects received a liquid meal, 10 others received a solid meal. With the liquid meal, gastric emptying was measured 15 min after its ingestion and antral contraction was measured for 15 min by ultrasonography. With the solid meal, gastric emptying was measured both by ultrasonography (n = 10) and by simultaneous scintigraphy (n = 6), with antral contraction measured by ultrasonography for 5 h after ingestion of the meal.
Octreotide given with a liquid or solid meal inhibited gastric emptying in healthy subjects. A significant suppression of antral contraction occurred only with a solid meal.
生长抑素对胃肠道的生理功能具有抑制作用。然而，其作用因测试餐、剂量及其他因素而异。
通过超声检查和闪烁扫描法确定生长抑素类似物奥曲肽对胃排空和胃窦收缩的影响。
20名健康男性；平均年龄23.9岁
对研究对象进行为期7天的观察，一次是在皮下注射50微克奥曲肽后，于摄入测试餐5分钟前进行，另一次是在皮下注射安慰剂后进行。10名研究对象接受流食，另外10名接受固体食物。对于流食，在摄入后15分钟测量胃排空情况，并通过超声检查测量胃窦收缩15分钟。对于固体食物，通过超声检查（n = 10）和同时进行闪烁扫描法（n = 6）测量胃排空情况，在摄入食物后通过超声检查测量胃窦收缩5小时。
与流食或固体食物同时给予奥曲肽可抑制健康受试者的胃排空。仅在给予固体食物时胃窦收缩出现显著抑制。
