Winnett A, Thomas S J, Brabin B J, Bain C, Alpers M A, Moss D J
Department of Social and Preventive Medicine, University of Queensland, Brisbane, Australia.
Br J Cancer. 1997;75(5):757-61. doi: 10.1038/bjc.1997.134.
A study of Burkitt's lymphoma (BL) in Papua New Guinea for the years 1958-87 revealed four instances of familial BL. Incident cases occurred within 1 year of each other in the four families. Personal follow-up was possible for three of these families whose pedigrees showed that two or more siblings were affected. There was no significant variation of the incidence of BL by year of diagnosis or month of onset. There was significant variation in annual average incidence of BL between the three provinces studied, with the highest incidence in the Nuku and Lumi census districts (of the West Sepik Province). This is the first report of familial BL outside Africa.
一项对1958年至1987年巴布亚新几内亚伯基特淋巴瘤(BL)的研究发现了4例家族性BL。这4个家庭中的发病病例在彼此1年内出现。其中3个家庭可以进行个人随访,其家系显示两个或更多兄弟姐妹受到影响。BL的发病率在诊断年份或发病月份上没有显著差异。在所研究的三个省份中,BL的年平均发病率存在显著差异,在(西塞皮克省的)努库和卢米普查区发病率最高。这是非洲以外关于家族性BL的首次报告。