Morrow R H, Pike M C, Smith P G
Br J Cancer. 1977 May;35(5):668-73. doi: 10.1038/bjc.1977.102.
All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findings in other areas of Uganda, there was no evidence of seasonal variation in the onset of cases, nor of space-time clustering, nor of a decline in the incidence of BL in the study period. An inverse relationship was noted between the median age at onset of BL and the incidence of the disease in different areas of Uganda, a finding consistent with intense malarial infection being a precipitating factor for BL. The variable observations with respect to space-time clustering of BL and seasonal variation in incidence in different areas remains unexplained, but it is suggested that a closer study of the patterns of malarial infection in these areas may help to account for the findings.
确定了1963年至1968年期间出现症状且居住在乌干达兰戈和阿乔利地区、所有在医院接受治疗的伯基特淋巴瘤（BL）病例。在这6年期间，BL的年均发病率为1.87×10⁻⁵，与相邻的西尼罗河地区相似。与乌干达其他地区的研究结果相反，在病例发病方面没有证据表明存在季节性变化、时空聚集现象，在研究期间BL的发病率也没有下降。在乌干达不同地区，BL发病的中位年龄与该疾病的发病率之间存在负相关关系，这一发现与严重疟疾感染是BL的诱发因素这一观点一致。关于BL的时空聚集以及不同地区发病率季节性变化的不同观察结果仍无法解释，但有人提出，对这些地区疟疾感染模式进行更深入的研究可能有助于解释这些发现。
