Salawu L, Fatusi O A, Kemi-Rotimi F, Adeodu O O, Durosinmi M A
Department of Haematology and Immunology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Ann Trop Paediatr. 1997 Dec;17(4):375-9. doi: 10.1080/02724936.1997.11747913.
Three Nigerian sib-pairs with familial Burkitt's lymphoma (BL) seen between 1986 and 1996 are described. Their ages ranged from 4 to 20 years (median 9.5), and there were five males and one female. The mean age interval between each pair at presentation was 4 years (3-6) and the mean time interval 22 months (0.3-41). Two of the sib-pairs were sex-concordant, including a set of monozygotic twins. Five of the patients presented in stage C and one in stage A. Parental consanguinity was not found in any group. Space-clustering was confirmed in all three but time-clustering in only one. The occurrence of BL in multiple members of the same family, the presence of sex concordance and the relatively wide variation in the time of onset of disease between each pair suggest genetic predisposition as a possible additional aetiological factor for BL in the families affected.
本文描述了1986年至1996年间发现的3个患有家族性伯基特淋巴瘤（BL）的尼日利亚同胞对。他们的年龄在4岁至20岁之间（中位数为9.5岁），其中有5名男性和1名女性。每对同胞在就诊时的平均年龄间隔为4岁（3 - 6岁），平均时间间隔为22个月（0.3 - 41个月）。其中2对同胞性别一致，包括一对同卵双胞胎。5例患者表现为C期，1例为A期。在任何一组中均未发现父母近亲结婚的情况。所有3组均证实存在空间聚集现象，但只有1组存在时间聚集现象。同一家庭的多名成员发生BL、性别一致的情况以及每对同胞之间疾病发病时间的相对广泛差异表明，遗传易感性可能是受影响家庭中BL的另一个可能病因。
