Espinasse F, Gheorghiu R, Poiata A, Labia R, Nicolas-Chanoine M H
Service de Microbiologie, Hôpital Ambroise Paré, Faculté de Médecine Paris Ouest, Boulogne, France.
J Antimicrob Chemother. 1997 Jan;39(1):103-6. doi: 10.1093/jac/39.1.103.
By determining the beta-lactam susceptibility of Enterobacteriaceae isolated in Eastern Romania from 1985 to 1993, three Escherichia coli, three Salmonella typhimurium and one Klebsiella pneumoniae isolates with reduced susceptibility to co-amoxiclav were found. The antibiotic susceptibility of the isolates and their E. coli derivatives, and kinetic values suggested the following resistance mechanisms: hyperproduction of TEM in S. typhimurium, limited antibiotic uptake in K. pneumoniae and OXA production in one strain of E. coli. Despite a normal beta-lactamase activity, the two remaining E. coli strains and their derivatives were less susceptible to co-amoxiclav.
