Hundley J E, Koester S K, Troyer D A, Hilsenbeck S G, Barrington R E, Windle J J
Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78284, USA.
Cancer Res. 1997 Feb 15;57(4):600-3.
We have used the MMTV-myc and MMTV-ras transgenic mouse mammary tumor models (T. A. Stewart et al., Cell, 38: 627-637, 1984, and E. Sinn et al., Cell, 49: 465-475, 1987) to evaluate how the c-myc and v-Ha-ras oncogenes influence tumor growth characteristics in vivo. MMTV-myc tumors had much higher levels of spontaneous apoptosis than MMTV-ras tumors, whereas intermediate levels were observed in MMTV-myc/ras tumors. Significant differences in cell cycle characteristics were also observed in tumors from mice of the three genotypes. Tumors from MMTV-myc mice had lower G1 and higher S-phase fractions than MMTV-ras tumors, with intermediate values again observed in the MMTV-myc/ras tumors. Despite these differences, however, tumor growth rates for the different groups were similar. These findings highlight the importance of the balance between cell cycle regulation and cell death in determining the kinetics of tumor growth and indicate that distinct oncogenes can have a profound influence on that balance.
我们利用MMTV - myc和MMTV - ras转基因小鼠乳腺肿瘤模型（T. A. 斯图尔特等人，《细胞》，第38卷：627 - 637页，1984年，以及E. 辛等人，《细胞》，第49卷：465 - 475页，1987年）来评估c - myc和v - Ha - ras癌基因如何在体内影响肿瘤生长特征。MMTV - myc肿瘤的自发凋亡水平比MMTV - ras肿瘤高得多 ，而在MMTV - myc/ras肿瘤中观察到的是中等水平。在三种基因型小鼠的肿瘤中也观察到细胞周期特征存在显著差异。与MMTV - ras肿瘤相比，MMTV - myc小鼠的肿瘤具有更低的G1期和更高的S期比例，在MMTV - myc/ras肿瘤中再次观察到中间值。然而，尽管存在这些差异，但不同组的肿瘤生长速率相似。这些发现突出了细胞周期调控与细胞死亡之间的平衡在决定肿瘤生长动力学方面的重要性，并表明不同的癌基因可对该平衡产生深远影响。
