Cardiff R D, Sinn E, Muller W, Leder P
Department of Pathology, School of Medicine, University of California, Davis 95616.
Am J Pathol. 1991 Sep;139(3):495-501.
The hypothesis that oncogenes influence tumor phenotype was tested by examining slides from 607 mammary tumors from 407 transgenic mice bearing the ras, myc, and/or neu oncogenes. Most tumors (91%) had patterns (phenotypes) that could not be classified by Dunn's standard nomenclature. The nonstandard tumors were described as eosinophilic small cell (SC), basophilic large cell (LC), or pale intermediate cell (IC). The SC tumor was associated with ras, the LC was associated with myc, and the IC was associated with neu, with specificities more than .90 and sensitivities ranging from .99 to .48. Thus, the tumor phenotype could be used to predict which oncogene was present in the animal. The presence of myc in combination with either ras or neu resulted in the predominance of LC tumors and accelerated tumorigenesis. The combination of ras and neu resulted in a decreased tumor incidence. Thus, knowledge of the oncogenes that were present could be used to predict the natural history of the disease.
通过检查来自407只携带ras、myc和/或neu癌基因的转基因小鼠的607个乳腺肿瘤的切片，对癌基因影响肿瘤表型这一假说进行了验证。大多数肿瘤（91%）具有无法用邓恩标准命名法分类的模式（表型）。这些非标准肿瘤被描述为嗜酸性小细胞（SC）、嗜碱性大细胞（LC）或淡色中间细胞（IC）。SC肿瘤与ras相关，LC与myc相关，IC与neu相关，特异性超过0.90，敏感性范围为0.99至0.48。因此，肿瘤表型可用于预测动物体内存在哪种癌基因。myc与ras或neu同时存在会导致LC肿瘤占优势并加速肿瘤发生。ras和neu的组合导致肿瘤发生率降低。因此，了解存在的癌基因可用于预测疾病的自然史。
