Reinhard T, Sundmacher R
Augenklinik der Heinrich-Heine-Universität, Düsseldorf.
Klin Monbl Augenheilkd. 1996 Oct;209(4):224-7. doi: 10.1055/s-2008-1035307.
It was the purpose of this prospective study to evaluate the effect of topical Ciclosporin 2% on epithelial and subepithelial opacities in Thygeson's superficial punctate keratitis.
We administered Ciclosporin A 2% eye drops to 31 eyes of 17 patients with Thygeson's superficial punctate keratitis. The initial dose was 3 drops daily during the first month. It was reduced according to the following scheme: 2 drops in the second month, 1 drop in the third month, 1 drop every second day in the fourth to sixth months. Thereafter therapy was stopped.
The opacities were suppressed completely in 21/31 eyes mostly after 4 weeks of therapy and incompletely in 8/31 eyes. Of the 21 eyes with complete suppression, 6/21 showed recurrent opacities when therapy was stopped after six months. 7/21 eyes had no recurrences after cessation of therapy. Follow-up of 8 eyes is currently less than 6 months and these eyes still receive Ciclosporin A 2% eye drops. All patients complained of a slight burning caused by the drops.
In the majority of patients with Thygeson's superficial punctate keratitis topical Ciclosporin A 2% suppresses epithelial and subepithelial opacities as long as this non-steroid therapy is administered at a low dose. In a considerable percentage therapy seems to be curative.
本前瞻性研究旨在评估2%环孢素局部用药对蒂格森浅层点状角膜炎上皮及上皮下混浊的影响。
我们对17例蒂格森浅层点状角膜炎患者的31只眼给予2%环孢素A滴眼液。首月初始剂量为每日3滴。之后按以下方案减量：第2个月2滴，第3个月1滴，第4至6个月每2日1滴。此后停止治疗。
31只眼中，21只眼的混浊在治疗约4周后完全得到抑制，8只眼未完全抑制。在21只混浊完全抑制的眼中，6只眼在6个月停药后出现混浊复发。21只眼中7只眼停药后未复发。8只眼的随访时间目前不足6个月，这些眼仍在使用2%环孢素A滴眼液。所有患者均主诉滴眼液引起轻微烧灼感。
对于大多数蒂格森浅层点状角膜炎患者，只要以低剂量给予这种非甾体治疗，局部使用2%环孢素A可抑制上皮及上皮下混浊。在相当比例的患者中，该治疗似乎具有治愈效果。
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