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自杀性中毒时强心苷对钾代谢的影响(作者译)

[Alteration of potassium metabolism by cardiac glycosides in suicidal intoxications (author's transl)].

作者信息

Heesen H, Schmiedeberg W

出版信息

Med Klin. 1977 Sep 2;72(35):1365-7.

PMID:904531
Abstract

The potassium concentrations in erythrocytes, serum and urine were continously determined in 3 patients who had taken acetyldigoxin (45 to 100 tablets Novodigal à 0,2 mg) in order to commit suicide. In the first 3 to 8 hours after ingestion of digitalis the potassium concentration in serum increased while the potassium concentration of erythrocytes declined a little. The elimination of potassium with the urine remained still normal. After this period of time the potassium concentration in serum and in erythrocytes considerably fell, simultaneously large amounts of potassium were excreted with the urine. It was not until after 14 days that the potassium metabolism normalized.

摘要

对3名因服用乙酰地高辛(45至100片,每片含新地高0.2毫克)自杀的患者,连续测定了其红细胞、血清和尿液中的钾浓度。在摄入洋地黄后的最初3至8小时内,血清钾浓度升高,而红细胞钾浓度略有下降。尿钾排泄仍属正常。在此之后,血清和红细胞中的钾浓度大幅下降,同时有大量钾随尿液排出。直到14天后钾代谢才恢复正常。

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