Kullmann F, Kullmann M, Leser H G, Krämer B K, Riegger A J, Schölmerich J
Klinik und Poliklinik für Innere Medizin I, Universität Regensburg.
Z Gastroenterol. 1996 Nov;34(11):757-62.
In february 1993, a now 54-year-old man presented with an increased serum-creatinine of 1.7 mg/dl known since september 1992 associated with peripheral edema. He reported painless and infrequent diarrhea during the previous 15 years. Clinically, he showed typical symptoms of a nephrotic syndrome. A renal biopsy revealed an amyloidosis. By further investigations the diagnosis of underlying Crohn's disease could be established. An ileocecal resection and a subsequent immunosuppressive therapy with azathioprine was performed. Following this procedure the serum-creatinine has meanwhile increased to 3.2 mg/dl with the proteinuria remaining stable. Furthermore, the patient developed a renal hypertension. However, at present the patient is otherwise asymptomatic and in a good general condition.
1993年2月，一名现年54岁的男性患者出现血清肌酐升高至1.7mg/dl，自1992年9月起即已出现，同时伴有外周水肿。他自述在过去15年中有无痛性且不频繁的腹泻。临床上，他表现出典型的肾病综合征症状。肾活检显示为淀粉样变性。通过进一步检查，确诊了潜在的克罗恩病。进行了回盲部切除术，随后使用硫唑嘌呤进行免疫抑制治疗。在此手术后，血清肌酐已升至3.2mg/dl，蛋白尿保持稳定。此外，患者出现了肾性高血压。然而，目前患者无其他症状，总体状况良好。
