大鼠对4-硝基喹啉1-氧化物诱导的舌癌易感性和抗性的遗传控制
Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.
作者信息
Kitano M, Hirayama Y, Tanuma J, Matsuuchi H, Miura Y, Li T J, Semba I, Ozaki H S, Kokubu T, Hatano H, Tada M, Kobayashi Y, Shisa H
机构信息
Department of Oral Pathology, Kagoshima University Dental School, Sakuragaoka.
出版信息
Jpn J Cancer Res. 1996 Nov;87(11):1097-101. doi: 10.1111/j.1349-7006.1996.tb03116.x.
We analyzed the incidence of infiltrative mass-type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4-nitroquinoline 1-oxide solution for 180 days. The study included various crosses of susceptible Dark-Agouti rats (DA) and resistant Wistar/Furth rats (WF). DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F1 and F2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.
我们分析了通过连续180天口服0.001%的4-硝基喹啉1-氧化物溶液诱导550只大鼠发生浸润性肿块型舌癌（IMTC）的发生率。该研究包括易感性暗褐鼠（DA）和抗性Wistar/Furth鼠（WF）的各种杂交组合。DA的IMTC发生率为93.6%，其最大直径超过5毫米，而WF的发生率仅为4%。由DA和WF杂交产生的正反交F1和F2杂种的发生率分别为47.5%和45.8%。同时，与DA和WF回交的正反交杂种的发生率分别为73.7%和24.6%。发生率的分离表明存在两个常染色体显性基因，一个与DA的易感性相关，另一个与WF的抗性相关。
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