Senger D R, Galli S J, Dvorak A M, Perruzzi C A, Harvey V S, Dvorak H F
Science. 1983 Feb 25;219(4587):983-5. doi: 10.1126/science.6823562.
Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.
豚鼠、仓鼠和小鼠的肿瘤腹水含有能迅速增加微血管通透性的活性物质。这些肿瘤细胞以及多种其他肿瘤细胞系在体外也会分泌类似的活性物质。从一种肿瘤（豚鼠10号肝癌细胞系）的培养基或腹水中纯化得到的增加通透性的活性物质是一种分子量为34000至42000道尔顿的蛋白质，与其他已知的通透性因子不同。
