Fujimitsu Y, Nakanishi H, Inada K, Yamachika T, Ichinose M, Fukami H, Tatematsu M
Laboratory of Pathology, Aichi Cancer Research Institute, Chikusa-ku, Nagoya.
Jpn J Cancer Res. 1996 Dec;87(12):1199-203. doi: 10.1111/j.1349-7006.1996.tb03133.x.
Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.
对出生后大鼠分离的结肠隐窝进行形态学分析表明，隐窝通过分裂机制自我繁殖，分裂从隐窝底部开始并向上进行，直至形成两个独立的隐窝。偶尔，在分离完成之前，一个分叉隐窝的一侧或两侧会开始第二个分裂过程，从而形成三叉或四叉隐窝。对用1,2 - 二甲基肼处理的大鼠分离的异常隐窝灶（ACF）进行分析发现，由多个隐窝组成的ACF的形成也是由于分裂机制。最初，单个ACF隐窝底部会出现一个凹陷，随后形成分叉，最终隐窝分裂。
