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Antitumor effect of Streptococcus pyogenes by inducing hydrogen peroxide production.化脓性链球菌通过诱导过氧化氢生成产生的抗肿瘤作用。
Jpn J Cancer Res. 1996 Dec;87(12):1271-9. doi: 10.1111/j.1349-7006.1996.tb03143.x.
2
Studies on the properties of a streptococcal preparation OK-432 (NSC-B116209) as an immunopotentiator. I. Activation of serum complement components and peritoneal exudate cells by group A streptococcus.作为免疫增强剂的链球菌制剂OK-432（NSC-B116209）的性质研究。I. A组链球菌对血清补体成分和腹腔渗出细胞的激活作用
Jpn J Exp Med. 1976 Apr;46(2):123-33.
3
Comparison of cytokine-inducing activity in a lipoteichoic acid-related molecule isolated from a penicillin-killed group A Streptococcus and from untreated bacteria.从青霉素处理致死的A组链球菌及未处理细菌中分离出的一种与脂磷壁酸相关分子的细胞因子诱导活性比较。
Int Immunopharmacol. 2001 Oct;1(11):1957-68. doi: 10.1016/s1567-5769(01)00123-0.
4
Antitumor activity of streptococcal acid glycoprotein produced by Streptococcus pyogenes Su.化脓性链球菌Su产生的链球菌酸性糖蛋白的抗肿瘤活性
Jpn J Cancer Res. 1987 Dec;78(12):1409-14.
5
Reduced antitumor and immune-adjuvant activities of the sub-cellular fractions from Group A Streptococcus.A组链球菌亚细胞组分的抗肿瘤和免疫佐剂活性降低。
Jpn J Exp Med. 1981 Dec;51(6):335-44.
6
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Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.OK-432衍生DNA的抗肿瘤作用：OK-432是一种链球菌免疫治疗剂，其活性成分之一。
J Immunother. 2006 Mar-Apr;29(2):143-50. doi: 10.1097/01.cji.0000189028.18288.6f.
8
Comparative experiments with hemolytic streptococcus and its anticancer preparations (OK-431 and OK-432) for their cytolytic activity.对溶血性链球菌及其抗癌制剂（OK-431和OK-432）的细胞溶解活性进行的对比实验。
Jpn J Exp Med. 1980 Feb;50(1):7-12.
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Role of interferon in the protective effect of an immunomodulator derived from the Su strain of Streptococcus pyogenes A3 against viral myocarditis in mice.干扰素在源自化脓性链球菌A3苏菌株的免疫调节剂对小鼠病毒性心肌炎保护作用中的作用。
Arzneimittelforschung. 1993 Jan;43(1):80-3.
10
Natural killer (NK) cell activating factor released from murine thymocytes stimulated with an anti-tumor streptococcal preparation, OK-432.
J Immunol. 1985 Feb;134(2):1039-47.

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本文引用的文献

1
Formation of a bacterial toxin (streptolysin S) by resting cells.静止细胞形成细菌毒素（链球菌溶血素S）。
J Exp Med. 1949 Nov;90(5):373-92. doi: 10.1084/jem.90.5.373.
2
Changes in oxygen tension in Yoshida ascites hepatoma during growth.吉田腹水肝癌生长过程中氧张力的变化
Proc Soc Exp Biol Med. 1967 Jul;125(3):853-6. doi: 10.3181/00379727-125-32222.
3
OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCCI. IV. STUDIES ON THE MECHANISM OF LYSIS BY CELL-BOUND HEMOLYSIN OF RED BLOOD CELLS AND EHRLICH ASCITES TUMOR CELLS.A组链球菌的氧稳定溶血素。IV. 关于红细胞和艾氏腹水肿瘤细胞的细胞结合溶血素的溶血机制研究。
J Exp Med. 1965 Apr 1;121(4):647-56. doi: 10.1084/jem.121.4.647.
4
The cytotoxic effects of hemolytic streptococci on ascites tumor cells.溶血性链球菌对腹水肿瘤细胞的细胞毒性作用。
Cancer Res. 1963 Jun;23:700-6.
5
Comparative experiments with hemolytic streptococcus and its anticancer preparations (OK-431 and OK-432) for their cytolytic activity.对溶血性链球菌及其抗癌制剂（OK-431和OK-432）的细胞溶解活性进行的对比实验。
Jpn J Exp Med. 1980 Feb;50(1):7-12.
6
Antitumor effects of hydrogen peroxide in vivo.过氧化氢在体内的抗肿瘤作用。
J Exp Med. 1981 Nov 1;154(5):1539-53. doi: 10.1084/jem.154.5.1539.
7
Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK-432.链球菌制剂OK-432增强小鼠自然杀伤细胞活性
J Natl Cancer Inst. 1980 Dec;65(6):1265-9.
8
Oxygen transport in vivo by means of perfluorochemical preparations.通过全氟化合物制剂在体内进行氧运输。
N Engl J Med. 1982 Jul 29;307(5):304-5. doi: 10.1056/NEJM198207293070509.
9
In vitro potentiation of human natural killer cell activity by a streptococcal preparation, OK-432: interferon and interleukin-2 participation in the stimulation with OK-432.一种链球菌制剂OK-432对人自然杀伤细胞活性的体外增强作用：干扰素和白细胞介素-2参与OK-432的刺激过程。
J Natl Cancer Inst. 1982 Oct;69(4):807-12.
10
In vitro augmentation of natural killing activity by OK-432.OK-432对自然杀伤活性的体外增强作用。
Int J Immunopharmacol. 1981;3(4):365-75. doi: 10.1016/0192-0561(81)90032-1.

化脓性链球菌通过诱导过氧化氢生成产生的抗肿瘤作用。

Antitumor effect of Streptococcus pyogenes by inducing hydrogen peroxide production.

作者信息

Higuchi Y

机构信息

Department of Pharmacology, Kanazawa University School of Medicine, Takara-machi, Ishikawa.

出版信息

Jpn J Cancer Res. 1996 Dec;87(12):1271-9. doi: 10.1111/j.1349-7006.1996.tb03143.x.

DOI:10.1111/j.1349-7006.1996.tb03143.x
PMID:9045963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921021/
Abstract

The Su strain of Streptococcus pyogenes (S-coccus)-derived anticancer preparation, OK-432, which is immobilized by heating in the presence of penicillin G, is well known to have an immunopotentiating activity through activation of natural killer cells in vivo. In this study, a streptococcal anticancer preparation stronger than OK-432 was prepared. Live streptococci (S-cocci) of the Su strain were induced to acquire H202-producing ability by treatment with serum under aerobic conditions. The resulting preparation no longer possessed hemolytic activity, and was not viable. The serum-treated S-coccus preparation activated natural killer cells as well as OK-432 did, and had stronger antitumor activity than OK-432 did. These results suggest that the serum-treated S-coccus preparation would be a useful tool for chemotherapy, in addition to immunotherapy, for the treatment of cancer.

摘要

化脓性链球菌（S 球菌）苏菌株衍生的抗癌制剂 OK-432，在青霉素 G 存在下经加热固定，众所周知其通过体内激活自然杀伤细胞具有免疫增强活性。在本研究中，制备了一种比 OK-432 更强的链球菌抗癌制剂。在有氧条件下用血清处理苏菌株的活链球菌（S 球菌），诱导其获得产生 H2O2 的能力。所得制剂不再具有溶血活性，且无活力。经血清处理的 S 球菌制剂与 OK-432 一样能激活自然杀伤细胞，并且具有比 OK-432 更强的抗肿瘤活性。这些结果表明，经血清处理的 S 球菌制剂除免疫疗法外，还将是癌症化疗的有用工具。