Harabuchi Y, Imai S, Kataura A, Osato T
Department of Otolaryngology, School of Medicine, Sapporo Medical University.
Nihon Rinsho. 1997 Feb;55(2):394-9.
The authors reviewed the clinical, phenotypic, genotypic, and Epstein-Barr virus (EBV)-findings of 18 patients with nasal T-cell lymphoma(NTL). The clinical features were characterized as prolonged fever, widespread dissemination into distant sites, and poor prognosis with median survival of only 6 months. EBV-encoded small nuclear early region(EBER) transcripts were identified in 16 of 18 patients. Monoclonal EBV genome, EBV-encoded nuclear antigen(EBNA)-1, and latent membrane protein(LMP)-1 were also detected in all EBER-positive cases tested. All EBV-positive NTL showed coexpression of natural killer(NK) cell phenotype CD56 and CD2. Of 9 EBV-positive NTL, seven cases expressed T-cell receptor (TCR)-delta chain with rearranged beta-, gamma- and/or delta- genes. These data suggest that some cases of EBV-positive NTL may be derived from the lineage of NK-like T-cells or gamma delta T-cells, and that EBV may play a role in the lymphomagenesis.
作者回顾了18例鼻型T细胞淋巴瘤（NTL）患者的临床、表型、基因型及爱泼斯坦-巴尔病毒（EBV）相关研究结果。临床特征表现为长期发热、广泛播散至远处部位以及预后较差，中位生存期仅6个月。18例患者中有16例检测到EBV编码的小核早期区域（EBER）转录本。在所有检测的EBER阳性病例中还检测到单克隆EBV基因组、EBV编码核抗原（EBNA）-1和潜伏膜蛋白（LMP）-1。所有EBV阳性NTL均显示自然杀伤（NK）细胞表型CD56和CD2共表达。在9例EBV阳性NTL中，7例表达T细胞受体（TCR）-δ链，伴有β、γ和/或δ基因重排。这些数据表明，部分EBV阳性NTL病例可能源自NK样T细胞或γδT细胞谱系，且EBV可能在淋巴瘤发生过程中发挥作用。
