Kanno H, Aozasa K
Department of Pathology, Osaka University Medical School.
Nihon Rinsho. 1997 Feb;55(2):436-40.
Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. Thus, the term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most of PALs are diffuse lymphomas of B cell type and contain Epstein-Barr virus (EBV) DNA. We established two lymphoma cell lines from biopsy specimens of PAL cases, and examined their growth characteristics and the expression of EBV latent infection genes and oncogenes. The differences in growth rate and oncogene expression between the lines could not be adequately explained by the pattern of EBV latent gene expression. The subsequent genetic lesions might be necessary for the development of overt lymphoma. Furthermore, the mechanism of development of viral antigen-positive tumor in immunocompetent patients is discussed.
恶性淋巴瘤常发生于长期脓胸患者的胸腔内。因此，已提出将这种类型的肿瘤称为脓胸相关淋巴瘤（PAL）。大多数PAL为B细胞型弥漫性淋巴瘤，并含有EB病毒（EBV）DNA。我们从PAL病例的活检标本中建立了两个淋巴瘤细胞系，并检测了它们的生长特性以及EBV潜伏感染基因和癌基因的表达。两株细胞系在生长速率和癌基因表达上的差异，无法通过EBV潜伏基因的表达模式得到充分解释。后续的基因损伤可能是明显淋巴瘤发生所必需的。此外，还讨论了免疫功能正常患者中病毒抗原阳性肿瘤的发生机制。
