Tanière P, Manai A, Charpentier R, Terdjman P, Boucheron S, Cordier J F, Berger F
Laboratoire d'Anatomie Pathologique de l'Hôpital E Herriot, Lyon, France.
Eur Respir J. 1998 Mar;11(3):779-83.
Pyothorax-associated lymphoma (PAL) is a newly-described entity developing several decades after artificial pneumothorax treatment for pulmonary or pleural tuberculosis. It is known to be associated with Epstein-Barr virus (EBV) with constant expression of the two latent membrane proteins: latent membrane protein (LMP)-1 and EBV-associated nuclear antigen (EBNA)-2. We are reporting three new cases of PAL. All of the tumours were of B-cell lineage and classified as large-cell diffuse lymphomas according to the International Working Formulation for the Classification of Lymphomas. The EBV genome was detected in two of the cases with LMP-1 and EBNA-2 expression. No EBV could be detected in the third case suggesting that different mechanisms may be involved in the pathogenesis of the disease. Body cavity-based high grade lymphomas (BCBL) represent a new disease, developing mainly in human immunodeficiency virus (HIV) infected patients: the tumoural cells often contain both human herpes virus (HHV)-8 (or Kaposi's sarcoma herpes virus) and EBV genomes, suggesting that these viruses might co-operate in the pathogenesis of the disease. The pleural location and the association of EBV have led to speculation that PAL could also be related to HHV-8 infection. However, no HHV-8 genome could be detected in any of the 14 tested cases already reported in the literature nor in the two cases we studied (one EBV-positive and one EBV-negative), suggesting that PAL and BCBL are two different entities.
脓胸相关性淋巴瘤（PAL）是一种新描述的疾病实体，在人工气胸治疗肺或胸膜结核数十年后发生。已知它与爱泼斯坦-巴尔病毒（EBV）相关，两种潜伏膜蛋白持续表达：潜伏膜蛋白（LMP）-1和EBV相关核抗原（EBNA）-2。我们报告3例新的PAL病例。所有肿瘤均为B细胞谱系，根据淋巴瘤分类的国际工作方案分类为大细胞弥漫性淋巴瘤。在2例病例中检测到EBV基因组，伴有LMP-1和EBNA-2表达。在第3例病例中未检测到EBV，提示该疾病的发病机制可能涉及不同的机制。体腔型高级别淋巴瘤（BCBL）是一种主要在人类免疫缺陷病毒（HIV）感染患者中发生的新疾病：肿瘤细胞通常同时含有人类疱疹病毒（HHV）-8（或卡波西肉瘤疱疹病毒）和EBV基因组，提示这些病毒可能在该疾病的发病机制中协同作用。PAL的胸膜部位及与EBV的关联引发了这样的推测，即PAL也可能与HHV-8感染有关。然而，在文献中已报道的14例检测病例以及我们研究的2例病例（1例EBV阳性和1例EBV阴性）中，均未检测到HHV-8基因组，提示PAL和BCBL是两种不同的疾病实体。
