Stefanadis C, Tsiamis E, Vlachopoulos C, Toutouzas K, Stratos C, Kallikazaros I, Vavuranakis M, Toutouzas P
Department of Cardiology, Hippokration Hospital, University of Athens, Greece.
Cathet Cardiovasc Diagn. 1997 Feb;40(2):217-22. doi: 10.1002/(sici)1097-0304(199702)40:2<217::aid-ccd25>3.0.co;2-m.
Recent studies have shown that stents may have a potential role in the treatment of thrombus-containing lesions. We report on the application of an autologous vein graft-coated stent (AVGCS) as the primary therapeutic modality for acute myocardial infarction in 10 patients. AVGCS delivery and deployment were successful and uneventful. Mean minimal lumen diameter and TIMI trial flow grade increased significantly (from 0.04 +/- 0.09 mm pre-AVGCS to 3.02 +/- 0.32 mm post-AVGCS, and from 10 patients with flow grade 0-1 pre-AVGCS to 10 patients with flow grade 3 post-AVGCS, respectively). Ten-day angiogram revealed maintenance of the immediate results. Nine patients had a negative exercise stress test 2 mo post-AVGCS, and at a mean follow-up of 30 +/- 7 weeks, all 9 were symptom-free. One patient, 3 wk after implantation and while being hospitalized for hypovolemic shock, developed recurrent infarction. These favorable preliminary outcomes suggest that AVGCS may play a useful role in the treatment of thrombus-containing lesions.
最近的研究表明，支架在含血栓病变的治疗中可能具有潜在作用。我们报告了10例急性心肌梗死患者应用自体静脉移植物涂层支架（AVGCS）作为主要治疗方式的情况。AVGCS的输送和植入成功且顺利。平均最小管腔直径和TIMI试验血流分级显著增加（分别从AVGCS植入前的0.04±0.09毫米增加到AVGCS植入后的3.02±0.32毫米，以及从AVGCS植入前10例血流分级为0 - 1级的患者变为AVGCS植入后10例血流分级为3级的患者）。术后10天的血管造影显示即刻效果得以维持。9例患者在AVGCS植入后2个月运动负荷试验结果为阴性，平均随访30±7周时，所有9例均无症状。1例患者在植入后3周因低血容量性休克住院期间发生了再梗死。这些良好的初步结果表明，AVGCS在含血栓病变的治疗中可能发挥有益作用。
