Goy R W, Deputte B L
The Department of Psychology, University of Wisconsin, Madison, USA.
Horm Behav. 1996 Dec;30(4):379-86. doi: 10.1006/hbeh.1996.0043.
Eight pregnant rhesus monkeys were injected with 100 microg diethylstilbestrol dipropionate (DESDP) from the 40th day of gestation until term, a long-term treatment. Male (n = 3) and female (n = 5) offspring were obtained. Five other pregnant females were injected with DESDP beginning on the 115th day of gestation and continuing until either the 140th day or term--a relatively short-term treatment. Five female infants were obtained from these short-term treatments. Monkeys from the treated pregnancies were assigned randomly to mother-infant social groups containing untreated male and female infants the same age. They were observed in their peer groups each weekday from 3 to 12 months of age, and the display of mounting and play behavior was recorded for each subject. Results showed that DESDP significantly increased the frequency of display of these juvenile behaviors only in long-term-treated females. However, one of the aspects of mounting that is characteristic of males (the ratio of complete to abortive mounts) was unaffected even by the long-term treatment. Thus, DESDP-treated females displayed a limited behavioral masculinization. Whether this limitation was due to dosage and/or timing or to a selective action of DESDP was not determined. DESDP-treated males were not altered in any measurable way compared to untreated males.
八只怀孕的恒河猴从妊娠第40天起至足月被注射100微克己烯雌酚二丙酸酯（DESDP），这是一种长期治疗。获得了雄性后代（n = 3）和雌性后代（n = 5）。另外五只怀孕的雌性恒河猴从妊娠第115天开始注射DESDP，并持续至第140天或足月，这是一种相对短期的治疗。从这些短期治疗中获得了五只雌性幼猴。将接受过治疗的怀孕母猴所生的幼猴随机分配到包含同龄未接受治疗的雄性和雌性幼猴的母婴社会群体中。在它们3至12个月大的每个工作日，观察它们在同伴群体中的表现，并记录每个个体的爬跨和玩耍行为。结果表明，DESDP仅在长期治疗的雌性幼猴中显著增加了这些幼年行为的表现频率。然而，即使是长期治疗，雄性爬跨行为的一个特征方面（完全爬跨与失败爬跨的比例）也未受影响。因此，接受DESDP治疗的雌性幼猴表现出有限的行为男性化。这种限制是由于剂量和/或时间，还是由于DESDP的选择性作用尚未确定。与未接受治疗的雄性相比，接受DESDP治疗的雄性在任何可测量的方面都没有改变。
