[头颈部皮肤肿瘤的化疗]
[Chemotherapy of skin tumors of the head and neck].
作者信息
Martins Mamede R C, de Góes Mascarenhas L, Junqueira Leite G, Ferreira A L
出版信息
Ann Otolaryngol Chir Cervicofac. 1979 Apr-May;96(4-5):241-9.
The authors report on the therapeutic results performed in the 126 skin tumors with three different chemotherapic schedules: a) Endovenous Bleomycin (BLM); b) Combined schedule with BLM, Methotrexate (MTX), Cyclophosphamide and Corticoid; c) Local BLM infiltration. There were 42,8 % of complete remission and 87,2 % of responsiveness (effectiveness). The best response rates were achieved in not advanced tumors. Local BLM infiltration has shown the best response rates 63,9 % being this schedule performed mainly in not advanced tumors. Overdosage of local infiltration may produce tissue necrose. Response rates for squamouscell carcinoma and basal cell carcinoma were alike. BMEM therapy presents the best results in the squamous cell carcinoma and the BLM infiltration in the basal cell carcinoma. There were 24 % of recurrence from the complete remissions.
作者报告了采用三种不同化疗方案对126例皮肤肿瘤进行治疗的结果：a）静脉注射博来霉素（BLM）；b）BLM、甲氨蝶呤（MTX）、环磷酰胺和皮质类固醇联合方案；c）局部BLM浸润。完全缓解率为42.8%，有效率（有效）为87.2%。在未进展的肿瘤中取得了最佳反应率。局部BLM浸润显示出最佳反应率，为63.9%，该方案主要用于未进展的肿瘤。局部浸润过量可能会导致组织坏死。鳞状细胞癌和基底细胞癌的反应率相似。BMEM疗法在鳞状细胞癌中效果最佳，而BLM浸润在基底细胞癌中效果最佳。完全缓解的病例中有24%复发。
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