Mamede R C, Mascarenhas L G
Ann Otolaryngol Chir Cervicofac. 1980 Oct-Nov;97(10-11):949-57.
The authors report on their findings after analysing the results of an intermittent combination chemotherapy with Bleomycin (B.L.M.), Methotrexate (M.T.X.), Cyclophosphamide and corticoid (B.M.E.M.), in 117 cases of tumors of the Head and Neck. There were 30,0% of complete remission and 77,8% of responsiveness mors. Significant response rates were achieved with this B.M.E.M. combination therapy in: both advanced and not advanced tumors, both well and poor differentiated carcinomas; both exophitic and endophytic tumors.
作者报告了他们对117例头颈部肿瘤患者采用博来霉素(B.L.M.)、甲氨蝶呤(M.T.X.)、环磷酰胺和皮质类固醇(B.M.E.M.)进行间歇联合化疗后的研究结果。完全缓解率为30.0%,有效率为77.8%。这种B.M.E.M.联合疗法在以下方面均取得了显著的有效率:晚期和非晚期肿瘤、高分化和低分化癌、外生性和内生性肿瘤。