Heimbach D, Jacobs D, Winter P, Süverkrüp R, Hesse A
Department of Urology, Rheinische Friedrich-Wilhelms-University, Medical School, Bonn, Germany.
Scand J Urol Nephrol. 1997 Feb;31(1):9-13. doi: 10.3109/00365599709070294.
Considered from a clinical point of view, all artificial stones known so far are inappropriate for experimental investigations, because they do not correspond to natural urinary stones in shape, physical properties and chemical composition. A special technique has now been developed for the production of biometric artificial stone models. Standard artificial carbonate apatite stones were produced by a coating technique where several layers of a suspension consisting of pure substance were applied around a core. Density and crushing strength of these ball-shaped artificial stones corresponded to natural apatite stones. Experimental chemolitholysis investigations showed comparable results in respect to the dissolution of artificial apatite stones and of natural stones of the same chemical composition. The disintegration behaviour was studied in ESWL tests which revealed a correlation between generator voltage and number of shock waves necessary for complete disintegration. For the first time, an artificial urinary stone has now been produced which is comparable to a natural stone of the same chemical composition not only in shape but also in its physical properties and lysis behaviour. These stones are suitable for use in systemic scientific investigations on disintegration and chemolitholysis.
从临床角度来看，迄今为止已知的所有人工结石都不适用于实验研究，因为它们在形状、物理性质和化学成分上与天然尿路结石不相符。目前已开发出一种特殊技术来生产生物特征人工结石模型。标准人工碳酸磷灰石结石是通过一种涂层技术生产的，即在一个核心周围施加几层由纯净物质组成的悬浮液。这些球形人工结石的密度和抗压强度与天然磷灰石结石相当。实验性化学溶石研究表明，在人工磷灰石结石和相同化学成分的天然结石的溶解方面，结果具有可比性。在体外冲击波碎石（ESWL）测试中研究了崩解行为，该测试揭示了发生器电压与完全崩解所需冲击波数量之间的相关性。现在首次生产出了一种人工尿路结石，它不仅在形状上，而且在物理性质和溶解行为上都与相同化学成分的天然结石相当。这些结石适用于关于崩解和化学溶石的系统性科学研究。
