Rodríguez-Puertas R, Nilsson S, Pascual J, Pazos A, Hökfelt T
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
J Neurochem. 1997 Mar;68(3):1106-13. doi: 10.1046/j.1471-4159.1997.68031106.x.
Using iodinated human galanin and autoradiography, galanin binding sites were studied in cortical and hippocampal areas and in some brainstem nuclei in the brains of eight patients with senile dementia of the Alzheimer type (SDAT) and of nine matched control cases. The highest density of binding sites was found in the substantia nigra with a less intense labeling in the hippocampus and cortical regions. In the SDAT cases a significant increase in number of galanin binding sites was found in some hippocampal areas, a decrease in the caudate nucleus, and no significant changes in frontal and entorhinal cortices. These findings suggest that some central galanin systems may be deranged in SDAT.
利用碘化人甘丙肽和放射自显影技术，对8例阿尔茨海默型老年痴呆（SDAT）患者及9例匹配的对照者大脑的皮质、海马区和一些脑干核团中的甘丙肽结合位点进行了研究。结合位点密度最高的是黑质，海马和皮质区域的标记强度较低。在SDAT病例中，发现海马某些区域的甘丙肽结合位点数量显著增加，尾状核减少，额叶和内嗅皮质无显著变化。这些发现提示，SDAT患者的一些中枢甘丙肽系统可能紊乱。
