Argyrokastritis A, Kamakari S, Kapsetaki M, Kritis A, Talianidis I, Moschonas N K
Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Heraklion, Greece.
Hum Genet. 1997 Feb;99(2):233-6. doi: 10.1007/s004390050345.
Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12-q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned.
人肝细胞核因子4（hHNF-4）是核激素受体超家族的成员，是肝脏特异性基因的重要转录因子和发育调节因子。最近已鉴定出与各种HNF-4亚型相对应的不同hHNF-4 cDNA。三个cDNA，即hHNF-4A、B和C，被认为是单个hHNF-4基因的剪接变体。我们通过遗传连锁分析，利用相邻的PstI限制性片段长度多态性（RFLP）以及荧光原位杂交，将hHNF-4定位到20q12-q13.1，位于PLCG1和D20S17之间。hHFN-4定位到20号染色体上与小鼠2号染色体同线的区域，其中已指定了hnf-4同源物。
