丙型流感病毒的受体破坏酶对抑制剂的灭活作用。

Inactivation of inhibitors by the receptor-destroying enzyme of influenza C virus.

作者信息

Höfling K, Klenk H D, Herrler G

机构信息

Institut für Virologie, Philipps-Universität Marburg, Germany.

出版信息

J Gen Virol. 1997 Mar;78 ( Pt 3):567-70. doi: 10.1099/0022-1317-78-3-567.

DOI:10.1099/0022-1317-78-3-567

PMID:9049406

Abstract

The importance of the receptor-destroying enzyme of influenza C virus for inactivation of inhibitors was analysed. Using three different inhibitors (rat serum, bovine submandibulary mucin and bovine brain gangliosides) inhibition of virus infection was observed only at an inhibitor concentration that was about 100-fold higher than the maximum concentration of inhibitor that could be inactivated by the receptor-destroying enzyme of a given amount of virus. From our data and other observations we conclude that the receptor-destroying enzyme is not required to inactivate inhibitors.

摘要

分析了丙型流感病毒的受体破坏酶对抑制剂失活的重要性。使用三种不同的抑制剂（大鼠血清、牛下颌下粘蛋白和牛脑神经节苷脂），仅在抑制剂浓度比给定数量病毒的受体破坏酶所能灭活的最大抑制剂浓度高约100倍时，才观察到对病毒感染的抑制作用。根据我们的数据和其他观察结果，我们得出结论，灭活抑制剂不需要受体破坏酶。