Padaiga Z, Tuomilehto J, Karvonen M, Podar T, Brigis G, Urbonaite B, Kohtamäki K, Lounamaa R, Tuomilehto-Wolf E, Reunanen A
Institute of Endocrinology, Kaunas Medical Academy, Lithuania.
Diabetologia. 1997 Feb;40(2):187-92. doi: 10.1007/s001250050661.
We present secular trends of childhood onset insulin-dependent diabetes mellitus (IDDM) in Finland, Estonia, Latvia and Lithuania during the period of 1983-1992. Incidence data were obtained from the national IDDM registries. The average age-standardized incidence per 100,000/year was 35.0 in Finland, followed by 10.2 in Estonia, 7.1 in Lithuania and 6.5 in Latvia. A male excess in incidence was recorded in Finland (1.15) and Latvia (1.01). In all countries, the highest age-specific risk of IDDM was observed in the 11-13 year age range. The large difference in incidence between Finland and other Baltic countries was see even in 1-2 year-old children. During the 10-year study period overall changes in incidence of IDDM were relatively small in these four countries. The incidence increased in Finland and Lithuania on average by 1% and 1.4% per year, respectively. A statistically significant increase was recorded only in 0-4 year old children in Finland, at 5.6% per year. In Estonia, an 8.3% increase in this age group, however, was not statistically significant. The different trends in the age-group specific incidence rates were confirmed in Finland. In conclusion, from 1983 to 1992 the incidence of childhood onset IDDM was increasingly in Finland and Lithuania, while in Latvia and Estonia it was stable. There are still great differences in IDDM incidence between the countries around the Baltic Sea.
我们呈现了1983年至1992年期间芬兰、爱沙尼亚、拉脱维亚和立陶宛儿童期发病的胰岛素依赖型糖尿病（IDDM）的长期趋势。发病率数据来自各国的IDDM登记处。芬兰每10万人/年的年龄标准化平均发病率为35.0，其次是爱沙尼亚的10.2、立陶宛的7.1和拉脱维亚的6.5。芬兰（1.15）和拉脱维亚（1.01）记录到男性发病率较高。在所有国家中，11 - 13岁年龄组的IDDM年龄特异性风险最高。即使在1 - 2岁的儿童中，也能看到芬兰与其他波罗的海国家之间发病率的巨大差异。在这10年的研究期间，这四个国家IDDM发病率的总体变化相对较小。芬兰和立陶宛的发病率分别平均每年增加1%和1.4%。仅在芬兰0 - 4岁儿童中记录到有统计学意义的增加，为每年5.6%。然而，爱沙尼亚这个年龄组8.3%的增加没有统计学意义。芬兰年龄组特异性发病率的不同趋势得到了证实。总之，1983年至1992年期间，芬兰和立陶宛儿童期发病的IDDM发病率呈上升趋势，而拉脱维亚和爱沙尼亚则保持稳定。波罗的海周边国家之间的IDDM发病率仍存在很大差异。
