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Mapping in the region of Danforth's short tail and the localization of tail length modifiers.

作者信息

Alfred J B, Rance K, Taylor B A, Phillips S J, Abbott C M, Jackson I J

机构信息

Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK.

出版信息

Genome Res. 1997 Feb;7(2):108-17. doi: 10.1101/gr.7.2.108.

DOI:10.1101/gr.7.2.108
PMID:9049629
Abstract

We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.

摘要

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