Frangou S, Sharma T, Alarcon G, Sigmudsson T, Takei N, Binnie C, Murray R M
Department of Psychological Medicine, King's College School of Medicine and Dentistry, London, UK.
Schizophr Res. 1997 Jan 17;23(1):45-53. doi: 10.1016/S0920-9964(96)00089-8.
Auditory event-related potentials (ERPs) were obtained from 33 schizophrenics, from 16 families multiply affected with schizophrenia, 57 of their non-schizophrenic first-degree relatives and 32 unrelated healthy controls. Transmission of schizophrenia in these families appeared unilinear with one parent only transmitting the disorder. Consequently, we were able to identify 10 presumed obligate carriers and study eight of them. Schizophrenic patients showed latency prolongation and amplitude reduction of the N100, N200 and P300 waves compared to controls. Their relatives showed similar abnormalities compared to controls. There was a trend for bimodal distribution of the P300 latency in the relatives, with 20 (35%) of them falling outside two standard deviations of the mean of the controls. These included six of the eight obligate carriers. Our results suggest that ERP abnormalities may serve as markers of genetic vulnerability in schizophrenia and may be useful in genetic linkage studies.
从33名精神分裂症患者、16个精神分裂症多发家庭、57名非精神分裂症一级亲属以及32名无关健康对照者身上获取了听觉事件相关电位（ERP）。这些家庭中精神分裂症的传递似乎是单系的，只有一位家长传递这种疾病。因此，我们能够识别出10名推定的 obligate 携带者，并对其中8人进行研究。与对照组相比，精神分裂症患者的N100、N200和P300波潜伏期延长、波幅降低。与对照组相比，他们的亲属也表现出类似的异常。亲属中P300潜伏期呈双峰分布趋势，其中20人（35%）超出对照组均值的两个标准差范围。这其中包括8名 obligate 携带者中的6人。我们的结果表明，ERP异常可能是精神分裂症遗传易感性的标志物，并且可能在基因连锁研究中有用。
