Zupi E, Luciano A A, Marconi D, Valli E, Patrizi G, Romanini C
12 Viale Parioli, 00197 Rome, Italy.
J Am Assoc Gynecol Laparosc. 1994 May;1(3):249-52. doi: 10.1016/s1074-3804(05)81018-7.
To determine whether the pain and discomfort of routine hysteroscopy with endometrial biopsy to diagnose infertility and endometrial pathology can be minimized by topical application of mepivacaine.
Prospective, randomized, double-blind study.
The Department of Obstetrics and Gynecology at a teaching hospital in Rome, Italy.
Eighteen women undergoing diagnostic hysteroscopy.
Hysteroscopy and endometrial biopsy were performed after transcervical injection of 5 ml 2% mepivacaine or 5 ml saline solution into the uterine cavity.
Difficulty introducing the hysteroscope was rated by the operator on a scale of 1 to 3. An observer scored visible signs of each woman's distress using a three-point scale. The patients reported their pain 15, 30, 60, 120 minutes after the procedure on a visual analog scale. Mepivacaine was more effective than placebo according to all measurements.
Topical mepivacaine reduced the pain experienced during and after hysteroscopy and endometrial biopsy.
