Vercellini P, Colombo A, Mauro F, Oldani S, Bramante T, Crosignani P G
Clinica Ostetrica e Ginecologica L. Mangiagalli, University of Milano, Italy.
Fertil Steril. 1994 Nov;62(5):1083-5.
One hundred seventy-seven women aged 41 +/- 8 (mean +/- SD) years, referred for evaluation of excessive uterine bleeding, were enrolled in an open-label randomized trial to evaluate the efficacy of local anesthesia before hysteroscopy in an outpatient population. The patients underwent hysteroscopy and endometrial biopsy with paracervical block by 10 mL of 1% mepivacaine hydrochloride solution (n = 87) or no local anesthesia (n = 90) and assessed lower abdominal and pelvic pain according to a 10-point linear analog scale. The mean +/- SD pain score was 4.5 +/- 2.0 at hysteroscopy and 5.2 +/- 2.1 at endometrial biopsy in the 87 subjects given a paracervical block versus 4.9 +/- 2.2 and 5.7 +/- 2.4 in the 90 women not given local anesthesia, without statistically significant differences. Paracervical anesthesia for routine outpatient hysteroscopy in premenopausal women may be superfluous.
177名年龄在41±8（平均±标准差）岁、因子宫异常出血前来评估的女性，被纳入一项开放标签随机试验，以评估门诊人群宫腔镜检查前局部麻醉的疗效。患者接受宫腔镜检查及子宫内膜活检，其中87例采用10毫升1%盐酸甲哌卡因溶液进行宫颈旁阻滞，90例不进行局部麻醉，根据10分线性模拟量表评估下腹部和盆腔疼痛。在接受宫颈旁阻滞的87名受试者中，宫腔镜检查时平均±标准差疼痛评分为4.5±2.0，子宫内膜活检时为5.2±2.1；而在未接受局部麻醉的90名女性中，相应评分分别为4.9±2.2和5.7±2.4，差异无统计学意义。绝经前女性常规门诊宫腔镜检查采用宫颈旁麻醉可能是多余的。
