Panconesi A, Sicuteri R
Institute of Internal Medicine IV, University of Florence, Italy.
Cephalalgia. 1997 Feb;17(1):3-14. doi: 10.1046/j.1468-2982.1997.1701003.x.
Serotonergic agonists such as m-chlorophenylpiperazine (m-CPP) and fenfluramine may induce migraine attacks. This has led to opposing theories concerning the role of 5-hydroxytryptamine (5HT) in triggering migraine attacks; is there hyperfunction or hypofunction of the central serotonergic system. Our review of the literature strongly suggests that m-CPP and fenfluramine provoke migraine attacks by stimulating, directly or indirectly, the 5HT2C/5HT2B receptors, although there is no total agreement with this interpretation. Central 5HT hypersensitivity in migraine patients, probably due to 5HT neuronal depletion, is proposed on the basis of review of electrophysiological tests and neuroendocrine challenge paradigms.
血清素能激动剂，如间氯苯哌嗪（m-CPP）和芬氟拉明，可能诱发偏头痛发作。这引发了关于5-羟色胺（5HT）在触发偏头痛发作中作用的相反理论：中枢血清素能系统是功能亢进还是功能减退？我们对文献的综述强烈表明，m-CPP和芬氟拉明通过直接或间接刺激5HT2C/5HT2B受体引发偏头痛发作，尽管对此解释尚无完全一致的看法。基于对电生理测试和神经内分泌激发模式的综述，有人提出偏头痛患者中枢5HT超敏反应可能是由于5HT神经元耗竭所致。
