Gordon M L, Lipton R B, Brown S L, van Praag H M
Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY.
Cephalalgia. 1995;15(4):292-6. doi: 10.1046/j.1468-2982.1995.1504292.x.
The neuroendocrine challenge paradigm provides a "window" on central neurotransmitter function in vivo. This strategy is based on the premise that the sensitivity of certain central receptors can be inferred from the magnitude of the hormonal response to specific pharmacologic probes. For example, the serotonin (5HT) receptor agonist m-chlorophenylpiperazine (m-CPP) stimulates the release of cortisol and prolactin and induces migraine-like headaches. We have previously reported that the headache and cortisol responses to m-CPP are highly correlated, which may implicate a disturbance in central serotonergic neurotransmission in the pathogenesis of migraine. As pharmacologic probes with greater specificity for 5HT receptor subtypes become available, we may be able to elucidate these mechanisms with greater precision. The neuroendocrine challenge methodology is also applicable to the study of other neurotransmitter systems and other headache disorders.
神经内分泌激发范式为体内中枢神经递质功能提供了一扇“窗口”。该策略基于这样一个前提，即某些中枢受体的敏感性可从对特定药理学探针的激素反应强度推断出来。例如，血清素（5-羟色胺，5HT）受体激动剂间氯苯哌嗪（m-CPP）可刺激皮质醇和催乳素的释放，并诱发偏头痛样头痛。我们之前曾报道，m-CPP引起的头痛和皮质醇反应高度相关，这可能意味着偏头痛发病机制中存在中枢5-羟色胺能神经传递紊乱。随着对5HT受体亚型具有更高特异性的药理学探针问世，我们或许能够更精确地阐明这些机制。神经内分泌激发方法也适用于其他神经递质系统和其他头痛疾病的研究。
