Toth E L, Lee K C, Couch R M, Martin L F
Department of Medicine, University of Alberta, Edmonton, Canada.
Diabetes Care. 1997 Mar;20(3):311-3. doi: 10.2337/diacare.20.3.311.
To determine the incidence of IDDM among children 0-14 years of age in Edmonton, Alberta, between 1990 and 1995 by means of a population-based registry.
Children < 15 years of age diagnosed with IDDM between January 1990 and December 1995 were registered according to criteria of the World Health Organization (WHO) Multinational Project for Childhood Diabetes. The primary source of case ascertainment consisted of office records of pediatricians and endocrinologists. The secondary source consisted of inpatient records from the main city hospitals.
Between 1990 and 1995, 211 IDDM patients < 15 years of age were detected by the two sources. All but 15 of them were of European ancestry. The ascertainment-corrected incidence rates of this ethnic group (constituting 77% of the population) for the 6 years were 38.6, 23.5, 23.3, 24.2, 22.0, and 24.3 per 100,000, respectively, with case ascertainment rates of 75-95%. The age-adjusted rate over the 6-year period was 25.7 per 100,000 with a case ascertainment rate of 84.3%. No sex difference was observed. The highest incidence occurred in the 10- to 14-year-old age-group, and more cases were detected between January and March than at other periods in the year.
The incidence of IDDM among the European-derived population in Edmonton between 1990 and 1995 is the highest rate over a 6-year period to be reported in North America, comparable to that in Prince Edward Island, Canada, and to the highest rates in the world.
通过基于人群的登记系统确定1990年至1995年间加拿大艾伯塔省埃德蒙顿市0至14岁儿童中胰岛素依赖型糖尿病（IDDM）的发病率。
1990年1月至1995年12月期间诊断为IDDM的15岁以下儿童，根据世界卫生组织（WHO）儿童糖尿病多国项目的标准进行登记。病例确定的主要来源包括儿科医生和内分泌科医生的办公室记录。次要来源包括主要城市医院的住院记录。
1990年至1995年间，通过这两个来源共检测到211例15岁以下的IDDM患者。除15例外，其余均为欧洲血统。该种族群体（占人口的77%）在6年中的校正发病率分别为每10万人38.6、23.5、23.3、24.2、22.0和24.3例，病例确定率为75%至95%。6年期间的年龄调整发病率为每10万人25.7例，病例确定率为84.3%。未观察到性别差异。发病率最高的是10至14岁年龄组，1月至3月期间检测到的病例比一年中的其他时期更多。
1990年至1995年间埃德蒙顿市欧洲裔人群中IDDM的发病率是北美报告的6年期间最高发病率，与加拿大爱德华王子岛的发病率相当，也是世界上最高的发病率之一。
