Tuomainen T P, Nyyssönen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan G A, Salonen J T
Research Institute of Public Health, University of Kuopio, Finland.
Diabetes Care. 1997 Mar;20(3):426-8. doi: 10.2337/diacare.20.3.426.
To study if there is an association between mildly elevated body iron and glucose homeostasis indexes.
A cross-sectional population study was conducted in 1,013 middle-aged men, and an association of serum ferritin with concentrations of serum insulin, blood glucose, and serum fructosamine was tested.
The mean concentration of fasting serum insulin was 21.6% higher (95% CI 7.3-37.9%, P < 0.001) in the 5th quintile of serum ferritin compared with the 1st quintile. The elevation in blood glucose was 6.1% (95% CI 2.3-9.9%, P < 0.001) and in serum fructosamine 3.9% (1.5-6.9%, P < 0.01).
Mildly elevated body iron stores are associated with statistically significant elevations in glucose homeostasis indexes.
