Corbett R J, Gee J, Laptook A R
Ralph Rogers and Mary Nell Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center at Dallas 75235-9085, USA.
Neuroreport. 1996 Dec 20;8(1):287-91. doi: 10.1097/00001756-199612200-00057.
Several algorithms for the calculation of ionized intracellular magnesium concentration from the chemical shifts of MgATP were compared, using in vivo 31P NMR data obtained from swine brain during and following hypoxic ischemia plus i.v. MgSO4 infusion. This analysis reveals that both the absolute ionized intracellular magnesium and relative changes in magnesium may vary widely between algorithms used. The calculated intracellular pH, used in algorithms to determine ionized magnesium concentration was found to be a critical parameter that governs the extent of these differences.
利用从猪脑在缺氧缺血期间及之后以及静脉注射硫酸镁期间获得的体内31P NMR数据，比较了几种根据MgATP化学位移计算细胞内游离镁浓度的算法。该分析表明，在使用的不同算法之间，细胞内游离镁的绝对值和镁的相对变化可能有很大差异。发现用于确定游离镁浓度的算法中的计算细胞内pH值是控制这些差异程度的关键参数。
