Collin P, Karvonen A L, Korpela M, Laippala P, Helin H
Dept. of Internal Medicine, Tampere University Hospital, Finland.
Scand J Gastroenterol. 1997 Feb;32(2):108-11. doi: 10.3109/00365529709000179.
According to some earlier reports, chronic atrophic gastritis is a common finding in Sjögren's syndrome. However, the findings are controversial. The aim of this study was to investigate the occurrence of gastritis classified in accordance with the Sydney System in patients with primary Sjögren's syndrome.
Thirty-two consecutive patients (27 women, 5 men) with primary Sjögren's syndrome, and 64 age- and sex-matched control subjects with dyspepsia underwent gastroscopic examination. Mucosal biopsy specimens were taken from the gastric antrum and corpus.
Eight (25%) patients with Sjögren's syndrome and three (4.1%) control subjects had atrophic antral gastritis (P = 0.01). Atrophic corpus gastritis was more frequently found in control subjects, but the difference was not statistically significant. None of the subjects had severe (grade 3) atrophy. Gastric inflammation, in either the corpus or antrum, was found in 85% of patients with Sjögren's syndrome and in 61% of control subjects (P = 0.02). Helicobacter pylori was present in 31% of Sjögren's syndrome patients and in 39% of controls (NS).
In patients with primary Sjögren's syndrome mild atrophic changes in the antrum were common, but severe mucosal atrophy was rare. Compared with control subjects, gastric inflammation was seen more often in patients with Sjögren's syndrome.
根据一些早期报告，慢性萎缩性胃炎在干燥综合征中很常见。然而，这些发现存在争议。本研究的目的是调查原发性干燥综合征患者中按照悉尼系统分类的胃炎的发生率。
连续32例原发性干燥综合征患者（27例女性，5例男性）和64例年龄及性别匹配的消化不良对照受试者接受了胃镜检查。从胃窦和胃体取黏膜活检标本。
8例（25%）干燥综合征患者和3例（4.1%）对照受试者有萎缩性胃窦炎（P = 0.01）。萎缩性胃体炎在对照受试者中更常见，但差异无统计学意义。所有受试者均无重度（3级）萎缩。85%的干燥综合征患者和61%的对照受试者在胃体或胃窦有胃炎（P = 0.02）。31%的干燥综合征患者和39%的对照受试者存在幽门螺杆菌（无显著差异）。
在原发性干燥综合征患者中，胃窦轻度萎缩性改变常见，但严重黏膜萎缩罕见。与对照受试者相比，干燥综合征患者中胃炎更常见。
