Pokorny G, Karácsony G, Lonovics J, Hudák J, Németh J, Varró V
First Department of Internal Medicine, Albert Szent-Györgyi Medical School, Szeged, Hungary.
Ann Rheum Dis. 1991 Feb;50(2):97-100. doi: 10.1136/ard.50.2.97.
Histological examination of the gastric mucosa was performed in 44 patients with primary Sjögren's syndrome with extraglandular symptoms (mean age 51.9, range 22-76). Biopsy specimens were taken from each of three separate regions: the antrum, the corpus, and the transitional zone between the antrum and the corpus. The incidence of chronic atrophic gastritis was considerably higher in patients with Sjögren's syndrome than in the controls. In the young patients with Sjögren's syndrome atrophic lesions were more common both in the antrum and in the corpus than in the control group. In middle aged patients, however, only the antrum, and in the elderly only the corpus, was much more commonly affected than in the controls. All three types of chronic atrophic gastritis occurred in patients with Sjögren's syndrome. Decreased gastric acid secretion was associated mainly with atrophic gastritis of types A and AB, whereas hypergastrinaemia occurred almost exclusively in gastritis of type A.
对44例伴有腺体外症状的原发性干燥综合征患者（平均年龄51.9岁，范围22 - 76岁）的胃黏膜进行了组织学检查。活检标本取自三个不同区域：胃窦、胃体以及胃窦与胃体之间的过渡区。干燥综合征患者慢性萎缩性胃炎的发生率显著高于对照组。在年轻的干燥综合征患者中，胃窦和胃体的萎缩性病变比对照组更常见。然而，在中年患者中，只有胃窦，而在老年患者中只有胃体，比对照组更常受累。干燥综合征患者中出现了所有三种类型的慢性萎缩性胃炎。胃酸分泌减少主要与A型和AB型萎缩性胃炎有关，而高胃泌素血症几乎仅发生在A型胃炎中。
