Islam S, Mahalanabis D, Chowdhury A K, Wahed M A, Rahman A S
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh.
Dig Dis Sci. 1997 Feb;42(2):420-3. doi: 10.1023/a:1018842708454.
L-Glutamine is the primary metabolic fuel of the intestinal mucosa. This in vivo study compares the effect of L-glutamine 50 mM with that of D-glucose 50 mM on water and electrolyte absorption in jejunal and ileal loops of healthy rabbits. Using polyethylene glycol (PEG) as a nonabsorbable marker and an incubation at 37 degrees C, we found that absorption of water (P = 0.000), sodium (P = 0.002), potassium (P = 0.001), and chloride (P = 0.003) from the glutamine electrolyte solution was greater than from the glucose electrolyte solution in the ileum. A similar trend was shown in the jejunum. We conclude that L-glutamine may be a useful component to be tested in oral rehydration solutions for treating diarrheal dehydration.
L-谷氨酰胺是肠黏膜的主要代谢燃料。这项体内研究比较了50 mM的L-谷氨酰胺与50 mM的D-葡萄糖对健康兔空肠和回肠肠袢中水和电解质吸收的影响。使用聚乙二醇（PEG）作为不可吸收标记物并在37℃下孵育，我们发现回肠中谷氨酰胺电解质溶液的水（P = 0.000）、钠（P = 0.002）、钾（P = 0.001）和氯（P = 0.003）吸收大于葡萄糖电解质溶液。空肠也显示出类似趋势。我们得出结论，L-谷氨酰胺可能是口服补液溶液中用于治疗腹泻性脱水的一种有用成分，有待进一步测试。
