Raimundo A H, Patil D H, Frost P G, Silk D B
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.
Gut. 1991 Mar;32(3):270-4. doi: 10.1136/gut.32.3.270.
The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.25 g/l, 1.0 g/l, jejunum; 0.5 g/l, 1.0 g/l, ileum; sulphasalazine 0.25 g/l, 0.5 g/l, 2.0 g/l jejunum; 1.0 g/l, 2.0 g/l, ileum.) In the jejunum olsalazine at 1.0 g/l significantly inhibited water, sodium, chloride, and potassium absorption (p less than 0.05). In the ileum olsalazine at 0.5 and 1 g/l significantly inhibited glucose uptake (p less than 0.04) and water absorption (p less than 0.03). In the jejunum sulphasalazine had a dose related and significant inhibitory effect on water, bicarbonate, and sodium absorption and at 2.0 g/l an inhibitory effect on chloride, potassium (p less than 0.005), and glucose (p less than 0.05) absorption. In the ileum sulphasalazine had no significant effect on water and electrolyte absorption. All inhibitory effects were rapidly reversible. These data show that unexplained diarrhoea in patients with ulcerative colitis treated with olsalazine may occur as a consequence of inhibition of water and electrolyte absorption in the small intestine and that the mechanisms of inhibition of sulphasalazine and olsalazine are different.
在正常受试者中，通过在不存在和存在浓度递增的每种药物的情况下，对生理葡萄糖碳酸氢盐电解质溶液进行稳态肠道灌注，研究了柳氮磺胺吡啶和奥沙拉嗪对空肠和回肠水及电解质吸收的影响。（奥沙拉嗪浓度：空肠0.25 g/l、1.0 g/l；回肠0.5 g/l、1.0 g/l；柳氮磺胺吡啶浓度：空肠0.25 g/l、0.5 g/l、2.0 g/l；回肠1.0 g/l、2.0 g/l。）在空肠中，1.0 g/l的奥沙拉嗪显著抑制水、钠、氯和钾的吸收（p<0.05）。在回肠中，0.5 g/l和1 g/l的奥沙拉嗪显著抑制葡萄糖摄取（p<0.04）和水吸收（p<0.03）。在空肠中，柳氮磺胺吡啶对水、碳酸氢盐和钠的吸收有剂量相关的显著抑制作用，在2.0 g/l时对氯、钾（p<0.005）和葡萄糖（p<0.05）的吸收有抑制作用。在回肠中，柳氮磺胺吡啶对水和电解质吸收无显著影响。所有抑制作用均可迅速逆转。这些数据表明，用奥沙拉嗪治疗的溃疡性结肠炎患者出现不明原因腹泻可能是小肠水和电解质吸收受抑制的结果，且柳氮磺胺吡啶和奥沙拉嗪的抑制机制不同。
